Rimonabant 20mg

Although the statistics suggest a market with enormous opportunity, pharmaceutical companies have so far been unable to capitalise on the need for anti-obesity agents. Only two drugs are approved for long-treatment of obesity. They are the lipase inhibitor orlistat, the leading medicine for weight reduction, and sibutramine.

Use of both products has been limited by side effects. In the prevailing market there is a clear opportunity for an effective and well-tolerated anti-obesity drug.

Although Acomplia rimonabant appeared efficacious, like previous anti-obesity drugs, safety issues have led to its withdrawal. Rimonabant is always considered as an anti smoking medicine. Some of the patients experienced and reported extreme anxiety levels after taking Rimonabant. Nausea and vomiting can be other side effects of rimonabant.

Acomplia is not meant for the use of pregnant women and those who are planning for a child. Activation of the peripheral endocannabinoid system in human obesity.

Mol Pharmacol Apr; 63 4: Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-indiced obesity.

J Clin Invest ; 5: Regulation, function and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycaemia.

J Clin Endocrin Metab ; 91 8: Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci May; 8 5: Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes Nov; 55 Warnings and Precautions to be taken when Using Rimonabant Tablets Before using Rimonabant Tablets please inform your doctor all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies.

It is advisable to consult a doctor before taking Rimonabant and adhere to the prescribed dosage to attain the expected results. Rimonabant should not be taken by pregnant woman since it may cause birth defects in an unborn baby.

Rimonabant should not also be used by lactating mothers. Though not clinically proved, there is possibility that this diet pill may be passed into breast milk. The RIO-Diabetes trial assessed the efficacy and safety of Rimonabant in overweight or obese patients with type 2 diabetes inadequately controlled by metformin or sulphonylureas.

Over overweight or obese type 2 diabetes patients with a haemoglobin A1c of 6. In this 6-month, randomized double-blind placebo-controlled trial, Rimonabant resulted in improvements in glycaemic control, body weight, and lipid profile in drug-naive type 2 diabetic patients [ 13 ].

Two meta-analyses [ 14 , 15 ] confirmed that Rimonabant treatment led to clinically meaningful weight loss, reduction in waist circumference, and improvements in several metabolic risk factors. However, findings from a meta-analysis of all published randomised controlled trials suggested that 20 mg per day Rimonabant increases the risk of psychiatric adverse events depressed mood disorders and anxiety despite depressed mood being an exclusion criterion in these trials.

Rimonabant caused significantly more adverse events than did placebo and 1. Patients given Rimonabant were 2. Furthermore, anxiety caused more patients to discontinue treatment in Rimonabant groups than in placebo groups.

Furthermore, two deaths from suicide were reported in patients taking Rimonabant. Approved, Investigational The serum concentration of Rimonabant can be increased when it is combined with Luliconazole.

Approved The metabolism of Rimonabant can be increased when combined with Lumacaftor. Approved The serum concentration of Rimonabant can be increased when it is combined with Mifepristone. Approved, Investigational The serum concentration of Rimonabant can be decreased when it is combined with Mitotane. Approved The metabolism of Rimonabant can be decreased when combined with Nefazodone. Approved, Withdrawn The metabolism of Rimonabant can be decreased when combined with Nelfinavir.

Approved The serum concentration of Rimonabant can be increased when it is combined with Netupitant. Approved The metabolism of Rimonabant can be increased when combined with Nevirapine. Approved The metabolism of Rimonabant can be decreased when combined with Nilotinib. Approved, Investigational The metabolism of Rimonabant can be decreased when combined with Olaparib.

Approved The serum concentration of Rimonabant can be increased when it is combined with Osimertinib. Approved The serum concentration of Rimonabant can be increased when it is combined with Palbociclib.

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